Hyperprolactinemia and selective serotonin reuptake inhibitors. a narrative review of the literature

Abstract

A large number of scientific papers have reported the relationship between the development of hyperprolactinemia and the
use of psychotropic drugs, especially the role of antipsychotics which are antidopaminergic drugs. However, less information is
known about the role of antidepressants in the development of hyperprolactinemia, specially the selective reuptake inhibitors
(SSRIs). The prevalence of hyperprolactinemia as a pharmacological side effect of SSRIs is still unknown, despite the widespread
use over the last decade. The aim of this review is to explore the relationship between hyperprolactinemia and SSRIs.